3,435 research outputs found
Ivermectin for onchocercal eye disease (river blindness).
BACKGROUND: It is believed that ivermectin (a microfilaricide) could prevent blindness due to onchocerciasis. However, when given to everyone in communities where onchocerciasis is common, the effects of ivermectin on lesions affecting the eye are uncertain and data on whether the drug prevents visual loss are unclear. OBJECTIVES: The aim of this review was to assess the effectiveness of ivermectin in preventing visual impairment and visual field loss in onchocercal eye disease. The secondary aim was to assess the effects of ivermectin on lesions affecting the eye in onchocerciasis. SEARCH METHODS: We searched CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2012, Issue 3), MEDLINE (January 1950 to April 2012), EMBASE (January 1980 to April 2012), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com), ClinicalTrials.gov (www.clinicaltrials.gov) and the WHO International Clinical Trials Registry Platform (ICTRP) (www.who.int/ictrp/search/en). We did not use any date or language restrictions in the electronic searches for trials. We last searched the electronic databases on 2 April 2012. SELECTION CRITERIA: We included randomised controlled trials with at least one year of follow-up comparing ivermectin with placebo or no treatment. Participants in the trials were people normally resident in endemic onchocercal communities with or without one or more characteristic signs of ocular onchocerciasis. DATA COLLECTION AND ANALYSIS: Two review authors independently extracted data and assessed trial quality. We contacted study authors for additional information. As trials varied in design and setting, we were unable to perform a meta-analysis. MAIN RESULTS: The review included four trials: two small studies (n = 398) in which people with onchocercal infection were given one dose of ivermectin or placebo and followed up for one year; and two larger community-based studies (n = 4941) whereby all individuals in selected communities were treated every six or 12 months with ivermectin or placebo, whether or not they were infected, and followed for two to three years. The studies provide evidence that treating people who have onchocerciasis with ivermectin reduces the number of microfilariae in their skin and eye(s) and reduces the number of punctate opacities. There was weaker evidence that ivermectin reduced the risk of chorioretinitis. The studies were too small and of too short a duration to provide evidence for an effect on sclerosing keratitis, iridocyclitis, optic nerve disease or visual loss. One community-based study in communities mesoendemic for the savannah strain of O.volvulus provided evidence that annual mass treatment with ivermectin reduces the risk of new cases of optic nerve disease and visual field loss. The other community-based study of mass biannual treatment of ivermectin in communities affected by the forest strain of O.volvulus demonstrated reductions in microfilarial load, punctate keratitis and iridocyclitis but not sclerosing keratitis, chorioretinitis, optic atrophy or visual impairment. The study was underpowered to estimate the effect of ivermectin on visual impairment and other less frequent clinical signs. The studies included in this review reported some adverse effects, in particular an increased risk of postural hypotension in people treated with ivermectin. AUTHORS' CONCLUSIONS: The lack of evidence for prevention of visual impairment and blindness should not be interpreted to mean that ivermectin is not effective, however, clearly this is a key question that remains unanswered. The main evidence for a protective effect of mass treatment with ivermectin on visual field loss and optic nerve disease comes from communities mesoendemic for the savannah strain of O.volvulus. Whether these findings can be applied to communities with different endemicity and affected by the forest strain is unclear. Serious adverse effects were rarely reported. None of the studies, however, were conducted in areas where people are infected with Loa loa (loiasis)
Distance Dependent Offsets between Parallaxes for Nearby Stars and Gaia DR1 Parallaxes
We use 612 single stars with previously published trigonometric parallaxes
placing them within 25 pc to evaluate parallaxes released in Gaia's first data
release (DR1). We find that the Gaia parallaxes are, on average, mas smaller than the weighted mean trigonometric parallax values for
these stars in the solar neighborhood. We also find that the offset changes
with distance out to 100 pc, in the sense that the closer the star, the larger
the offset. We find no systematic trends in the parallax offsets with stellar
magnitude, color, or proper motion. We do find that the offset is
roughly twice as large for stars south of the ecliptic compared to those that
are north.Comment: 14 pages, 2 figures, 3 tables, accepted for publication in ApJ
Letter. The table 1 is available in its entirety in a machine-readable form
in the online journa
The Specific Globular Cluster Frequencies of Dwarf Elliptical Galaxies from the Hubble Space Telescope
The specific globular cluster frequencies (S_N) for 24 dwarf elliptical (dE)
galaxies in the Virgo and Fornax Clusters and the Leo Group imaged with the
Hubble Space Telescope are presented. Combining all available data, we find
that for nucleated dEs --- which are spatially distributed like giant
ellipticals in galaxy clusters --- S_N(dE,N)=6.5 +- 1.2 and S_N increases with
M_V, while for non-nucleated dEs --- which are distributed like late-type
galaxies --- S_N(dE,noN)=3.1 +- 0.5 and there is little or no trend with M_V.
The S_N values for dE galaxies are thus on average significantly higher than
those for late-type galaxies, which have S_N < 1. This suggests that dE
galaxies are more akin to giant Es than to late-type galaxies. If there are
dormant or stripped irregulars hiding among the dE population, they are likely
to be among the non-nucleated dEs. Furthermore, the similarities in the
properties of the globular clusters and in the spatial distributions of dE,Ns
and giant Es suggest that neither galaxy mass or galaxy metallicity is
responsible for high values of S_N. Instead, most metal-poor GCs may have
formed in dwarf-sized fragments that merged into larger galaxies.Comment: 12 pages (uses aaspp4.sty), 2 figures, 1 table, to appear in the
Astrophysical Journa
A 4-Planet System Orbiting the K0V Star HD 141399
We present precision radial velocity (RV) data sets from Keck-HIRES and from
Lick Observatory's new Automated Planet Finder Telescope and Levy Spectrometer
on Mt. Hamilton that reveal a multiple-planet system orbiting the nearby,
slightly evolved, K-type star HD 141399. Our 91 observations over 10.5 years
suggest the presence of four planets with orbital periods of 94.35, 202.08,
1070.35, and 3717.35 days and minimum masses of 0.46, 1.36, 1.22, and 0.69
Jupiter masses respectively. The orbital eccentricities of the three inner
planets are small, and the phase curves are well sampled. The inner two planets
lie just outside the 2:1 resonance, suggesting that the system may have
experienced dissipative evolution during the protoplanetary disk phase. The
fourth companion is a Jupiter-like planet with a Jupiter-like orbital period.
Its orbital eccentricity is consistent with zero, but more data will be
required for an accurate eccentricity determination.Comment: 11 pages, 13 figures, To appear in the Astrophysical Journa
The Solar Neighborhood. XXXIV. A Search for Planets Orbiting Nearby M Dwarfs using Astrometry
Astrometric measurements are presented for seven nearby stars with previously
detected planets: six M dwarfs (GJ 317, GJ 667C, GJ 581, GJ 849, GJ 876, and GJ
1214) and one K dwarf (BD 10 3166). Measurements are also presented for six
additional nearby M dwarfs without known planets, but which are more favorable
to astrometric detections of low mass companions, as well as three binary
systems for which we provide astrometric orbit solutions. Observations have
baselines of three to thirteen years, and were made as part of the RECONS
long-term astrometry and photometry program at the CTIO/SMARTS 0.9m telescope.
We provide trigonometric parallaxes and proper motions for all 16 systems, and
perform an extensive analysis of the astrometric residuals to determine the
minimum detectable companion mass for the 12 M dwarfs not having close stellar
secondaries. For the six M dwarfs with known planets, we are not sensitive to
planets, but can rule out the presence of all but the least massive brown
dwarfs at periods of 2 - 12 years. For the six more astrometrically favorable M
dwarfs, we conclude that none have brown dwarf companions, and are sensitive to
companions with masses as low as 1 for periods longer than two years.
In particular, we conclude that Proxima Centauri has no Jovian companions at
orbital periods of 2 - 12 years. These results complement previously published
M dwarf planet occurrence rates by providing astrometrically determined upper
mass limits on potential super-Jupiter companions at orbits of two years and
longer. As part of a continuing survey, these results are consistent with the
paucity of super-Jupiter and brown dwarf companions we find among the over 250
red dwarfs within 25 pc observed longer than five years in our astrometric
program.Comment: 18 pages, 5 figures, 4 tables, accepted for publication in A
Dynamical Friction in dE Globular Cluster Systems
The dynamical friction timescale for globular clusters to sink to the center
of a dwarf elliptical galaxy (dE) is significantly less than a Hubble time if
the halos have King-model or isothermal profiles and the globular clusters
formed with the same radial density profile as the underlying stellar
population. We examine the summed radial distribution of the entire globular
cluster systems and the bright globular cluster candidates in 51 Virgo and
Fornax Cluster dEs for evidence of dynamical friction processes. We find that
the summed distribution of the entire globular cluster population closely
follows the exponential profile of the underlying stellar population. However,
there is a deficit of bright clusters within the central regions of dEs
(excluding the nuclei), perhaps due to the orbital decay of these massive
clusters into the dE cores. We also predict the magnitude of each dE's nucleus
assuming the nuclei form via dynamical friction. The observed trend of
decreasing nuclear luminosity with decreasing dE luminosity is much stronger
than predicted if the nuclei formed via simple dynamical friction processes. We
find that the bright dE nuclei could have been formed from the merger of
orbitally decayed massive clusters, but the faint nuclei are several magnitudes
fainter than expected. These faint nuclei are found primarily in M_V > -14 dEs
which have high globular cluster specific frequencies and extended globular
cluster systems. In these galaxies, supernovae-driven winds, high central dark
matter densities, extended dark matter halos, the formation of new star
clusters, or tidal interactions may act to prevent dynamical friction from
collapsing the entire globular cluster population into a single bright nucleus.Comment: 15 pages, 2 tables, 7 figures; to appear in the Astrophysical
Journal, April 20, 200
The Solar Neighborhood XXV: Discovery of New Proper Motion Stars with 0.40 "/yr > mu > 0.18 "/yr between Declinations -47 degrees and 00 degrees
We present 2817 new southern proper motion systems with 0.40 "/yr > mu > 0.18
"/yr and declination between -47 degrees and 00 degrees. This is a continuation
of the SuperCOSMOS-RECONS (SCR) proper motion searches of the southern sky. We
use the same photometric relations as previous searches to provide distance
estimates based on the assumption that the objects are single main sequence
stars. We find 79 new red dwarf systems predicted to be within 25 pc, including
a few new components of previously known systems. Two systems - SCR 1731-2452
at 9.5 pc and SCR 1746-3214 at 9.9 pc - are anticipated to be within 10 pc. We
also find 23 new white dwarf candidates with distance estimates of 15-66 pc, as
well as 360 new red subdwarf candidates. With this search, we complete the SCR
sweep of the southern sky for stars with mu > 0.18 "/yr and R_59F < 16.5,
resulting in a total of 5042 objects in 4724 previously unreported proper
motion systems. Here we provide selected comprehensive lists from our SCR
proper motion search to date, including 152 red dwarf systems estimated to be
within 25 pc (nine within 10 pc), 46 white dwarfs (ten within 25 pc), and 598
subdwarf candidates. The results of this search suggest that there are more
nearby systems to be found at fainter magnitudes and lower proper motion limits
than those probed so far.Comment: 47 pages, 16 of text. 7 figure
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